Volume-sensitive taurine transport in bovine articular chondrocytes.
نویسندگان
چکیده
منابع مشابه
0925 - Characterisation of Lactic Acid Transport in Bovine Articular Chondrocytes
INTRODUCTION The avascular environment of the articular chondrocyte dictates that metabolism is largely by anaerobic pathways, with the consequent production of large quantities of lactic acid. The lactic acid produced by chondrocytes must diffuse from the cells, through the extracellular matrix to the synovial fluid and thereafter to capillaries and the systemic circulation. There are reports ...
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Immune rejection is a major concern for any allogeneic or xenogeneic graft. For in vivo investigations of cartilage tissue engineering strategies, small animal models such as the leporine model are commonly employed. Many studies report little to no immune rejection upon allogeneic or xenogeneic implantation of native articular and meniscal cartilages. This study investigated whether bovine and...
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Cultured bovine aortic endothelial (BAE) cells expressed a Na(+)/Cl(-)-dependent taurine uptake activity that saturated with an apparent K(0.5) of approximately 4.9 microM for taurine and was inhibited by beta-alanine, guanidinoethane sulfonate, and homotaurine. We isolated a taurine transporter clone from a BAE cell cDNA library that revealed >91% sequence identity at the amino acid level to t...
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Articular cartilage is characterized by the lack of blood vessels and has a poor self-healing potential. Limited cell numbers and dedifferentiation of chondrocytes when expanded in vitro are the major obstacles of autologous chondrocyte implantation. Autologous chondrocyte implantation is a cell-based treatment that can be used as a second-line measure to regenerate chondral or osteochondral de...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1995
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1995.sp020701